| p38 alpha has been widely validated as a target for inflammatory diseases such as rheumatoid arthritis, asthma, COPD, and psoriasis. The p38 gene plays a critical role in the production of certain cytokines by modulating the response to environmental stress and inflammation through phosphorylating key downstream proteins. p38 alpha has also been implicated in cancer, central nervous system disorders, and diabetes. |
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| Xcovery's p38 therapeutic is a small molecule which will reduce or cease the production of TNF-alpha and IL-1. These compounds potentially address the $13B annual market for branded anti-inflammatory therapies and/or the unmet need for effective topical psoriasis treatment. |
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